Yes. EDDP is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 50 ng/mL. It is a breakdown product of methadone. EDDP is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) is the main metabolite of methadone, formed as the liver processes the medicine.
EDDP has no medical use of its own; it appears after methadone is taken.
Because EDDP comes from Methadone, the two are reported side by side and read together.
EDDP is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports EDDP as detected when its concentration is at or above the cut-off of 50 ng/mL, within a reportable range of 50–10,000 ng/mL. It is one of 16 compounds in the opioids and their metabolites family on the 76-drug confirmation panel.
The laboratory's confirmation report lists an approximate detection window of 3-11 days for EDDP. Treat that as a rough guide only: how long any compound stays measurable varies with the amount taken, how often it is used, body composition, metabolism, kidney and liver function, and hydration. A laboratory result cannot be used to work out when a substance was taken.
EDDP is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
EDDP is especially useful in methadone treatment programs because it can only be present if methadone passed through the body, which helps show a sample reflects real use rather than methadone added directly to the specimen.
Prescription opioid pain medicines, heroin markers and the compounds the body makes from them. Measuring metabolites alongside parent drugs shows a drug was actually processed by the body.
Yes. EDDP is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 50 ng/mL. It is a breakdown product of methadone. EDDP is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
LabX reports EDDP as detected at or above 50 ng/mL, and the method's reportable range is 50–10,000 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.
The laboratory lists an approximate window of 3-11 days, but it varies with dose, frequency of use, metabolism and hydration, and cannot be used to tell when something was taken.
EDDP is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
EDDP has no medical use of its own; it appears after methadone is taken.
EDDP is a breakdown product of methadone. Laboratories measure it because it shows the parent drug was actually processed by the body.
Terms on this page: metabolite · cut-off · detection window · presumptive result · confirmation test. More questions: LabX answers.
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