Opioids and their metabolites

Does a drug test detect Codeine?

Yes. Codeine is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 50 ng/mL. The LabX 12-panel screen includes a Opiates line designed to pick up Codeine. A screen is presumptive; adding laboratory confirmation identifies Codeine specifically.

50 ng/mLLaboratory cut-off
50–10,000 ng/mLReportable range
1-3 daysApprox. window (varies)
LC-MS/MSConfirmation method

What is Codeine?

Codeine is a naturally occurring opioid found in the opium poppy. In the body, part of a codeine dose is converted into morphine, which is one reason codeine and morphine are often seen together on a laboratory report.

Also known as or found in: Tylenol with Codeine.

Medical use

Codeine is prescribed for mild to moderate pain, often combined with acetaminophen, and in some cough preparations. Availability of codeine cough products varies by state and product.

How LabX tests for Codeine

Codeine is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports Codeine as detected when its concentration is at or above the cut-off of 50 ng/mL, within a reportable range of 50–10,000 ng/mL. It is one of 16 compounds in the opioids and their metabolites family on the 76-drug confirmation panel.

Detection window

The laboratory's confirmation report lists an approximate detection window of 1-3 days for Codeine. Treat that as a rough guide only: how long any compound stays measurable varies with the amount taken, how often it is used, body composition, metabolism, kidney and liver function, and hydration. A laboratory result cannot be used to work out when a substance was taken.

Screen versus confirmation

The LabX 12-panel screen includes a Opiates line designed to pick up Codeine. A screen is presumptive; adding laboratory confirmation identifies Codeine specifically.

Worth knowing

Because codeine is partly converted to morphine, and because poppy seeds can contain small amounts of both, a laboratory result showing codeine and morphine together has several possible explanations. Interpreting that pattern alongside prescriptions is a job for a licensed physician or Medical Review Officer.

About this drug family

Prescription opioid pain medicines, heroin markers and the compounds the body makes from them. Measuring metabolites alongside parent drugs shows a drug was actually processed by the body.

Common questions

Does a drug test detect Codeine?

Yes. Codeine is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 50 ng/mL. The LabX 12-panel screen includes a Opiates line designed to pick up Codeine. A screen is presumptive; adding laboratory confirmation identifies Codeine specifically.

What is the laboratory cut-off for Codeine?

LabX reports Codeine as detected at or above 50 ng/mL, and the method's reportable range is 50–10,000 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.

How long can Codeine be detected?

The laboratory lists an approximate window of 1-3 days, but it varies with dose, frequency of use, metabolism and hydration, and cannot be used to tell when something was taken.

Can a 12-panel drug screen detect Codeine?

The LabX 12-panel screen includes a Opiates line designed to pick up Codeine. A screen is presumptive; adding laboratory confirmation identifies Codeine specifically.

Is Codeine a prescription medicine?

Codeine is prescribed for mild to moderate pain, often combined with acetaminophen, and in some cough preparations. Availability of codeine cough products varies by state and product.

Related compounds

Terms on this page: metabolite Β· cut-off Β· detection window Β· presumptive result Β· confirmation test. More questions: LabX answers.

Test for Codeine and 75 other compounds

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At-home drug tests and test kits are not currently available to addresses in New York, New Jersey, Rhode Island or California. Results are not a diagnosis β€” review them with a licensed physician.

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Talk to a licensed physician. LabX Diagnostics and Vantage provide laboratory testing only. The information on this page is educational and is not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about test results, symptoms or medicines, and before making any health decision. If you think you may have a medical emergency, call 911. Read our medical disclaimer.

Medical disclaimer. LabX Diagnostics and Vantage provide laboratory testing only. Test results and information on this site are for informational purposes and are not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about your results and before making any health decision. If you think you may have a medical emergency, call 911. Read the full disclaimer.

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