Opioids and their metabolites

Does a drug test detect Tapentadol?

Yes. Tapentadol is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 50 ng/mL. Tapentadol is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

50 ng/mLLaboratory cut-off
50–5,000 ng/mLReportable range
1-3 daysApprox. window (varies)
LC-MS/MSConfirmation method

What is Tapentadol?

Tapentadol is a synthetic pain medicine that acts on opioid receptors and blocks the reuptake of norepinephrine. It is a federally controlled (Schedule II) substance.

Also known as or found in: Nucynta.

Medical use

Tapentadol is prescribed for acute pain and, in an extended-release form, for certain chronic pain conditions including diabetic nerve pain.

How LabX tests for Tapentadol

Tapentadol is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports Tapentadol as detected when its concentration is at or above the cut-off of 50 ng/mL, within a reportable range of 50–5,000 ng/mL. It is one of 16 compounds in the opioids and their metabolites family on the 76-drug confirmation panel.

Detection window

The laboratory's confirmation report lists an approximate detection window of 1-3 days for Tapentadol. Treat that as a rough guide only: how long any compound stays measurable varies with the amount taken, how often it is used, body composition, metabolism, kidney and liver function, and hydration. A laboratory result cannot be used to work out when a substance was taken.

Screen versus confirmation

Tapentadol is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

Worth knowing

Tapentadol is not picked up by standard opiate screens. Our LC-MS/MS confirmation measures both tapentadol and its metabolite N-desmethyltapentadol.

About this drug family

Prescription opioid pain medicines, heroin markers and the compounds the body makes from them. Measuring metabolites alongside parent drugs shows a drug was actually processed by the body.

Common questions

Does a drug test detect Tapentadol?

Yes. Tapentadol is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 50 ng/mL. Tapentadol is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

What is the laboratory cut-off for Tapentadol?

LabX reports Tapentadol as detected at or above 50 ng/mL, and the method's reportable range is 50–5,000 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.

How long can Tapentadol be detected?

The laboratory lists an approximate window of 1-3 days, but it varies with dose, frequency of use, metabolism and hydration, and cannot be used to tell when something was taken.

Can a 12-panel drug screen detect Tapentadol?

Tapentadol is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

Is Tapentadol a prescription medicine?

Tapentadol is prescribed for acute pain and, in an extended-release form, for certain chronic pain conditions including diabetic nerve pain.

Related compounds

Terms on this page: metabolite Β· cut-off Β· detection window Β· presumptive result Β· confirmation test. More questions: LabX answers.

Test for Tapentadol and 75 other compounds

12-panel urine $89 or fingerstick blood $99, plus the 76-drug LC-MS/MS confirmation for +$89.

At-home drug tests and test kits are not currently available to addresses in New York, New Jersey, Rhode Island or California. Results are not a diagnosis β€” review them with a licensed physician.

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Talk to a licensed physician. LabX Diagnostics and Vantage provide laboratory testing only. The information on this page is educational and is not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about test results, symptoms or medicines, and before making any health decision. If you think you may have a medical emergency, call 911. Read our medical disclaimer.

Medical disclaimer. LabX Diagnostics and Vantage provide laboratory testing only. Test results and information on this site are for informational purposes and are not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about your results and before making any health decision. If you think you may have a medical emergency, call 911. Read the full disclaimer.

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