Yes. Norbuprenorphine is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 10 ng/mL. It is a breakdown product of buprenorphine. Norbuprenorphine is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
Norbuprenorphine is the main metabolite of buprenorphine, formed in the liver. It is not prescribed on its own.
Norbuprenorphine has no separate medical use; it reflects buprenorphine that has been metabolized.
Because Norbuprenorphine comes from Buprenorphine, the two are reported side by side and read together.
Norbuprenorphine is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports Norbuprenorphine as detected when its concentration is at or above the cut-off of 10 ng/mL, within a reportable range of 10β2,500 ng/mL. It is one of 5 compounds in the opioid treatment and reversal family on the 76-drug confirmation panel.
The laboratory's confirmation report lists an approximate detection window of 0.5 to 1 day for Norbuprenorphine. Treat that as a rough guide only: how long any compound stays measurable varies with the amount taken, how often it is used, body composition, metabolism, kidney and liver function, and hydration. A laboratory result cannot be used to work out when a substance was taken.
Norbuprenorphine is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
Buprenorphine present without norbuprenorphine is a pattern treatment programs pay attention to, because it can suggest the medicine did not pass through the body. Only a licensed physician should interpret that in context.
Medicines used to treat opioid and alcohol use disorder or to reverse an overdose, with their metabolites, as monitored in treatment programs.
Yes. Norbuprenorphine is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 10 ng/mL. It is a breakdown product of buprenorphine. Norbuprenorphine is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
LabX reports Norbuprenorphine as detected at or above 10 ng/mL, and the method's reportable range is 10β2,500 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.
The laboratory lists an approximate window of 0.5 to 1 day, but it varies with dose, frequency of use, metabolism and hydration, and cannot be used to tell when something was taken.
Norbuprenorphine is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
Norbuprenorphine has no separate medical use; it reflects buprenorphine that has been metabolized.
Norbuprenorphine is a breakdown product of buprenorphine. Laboratories measure it because it shows the parent drug was actually processed by the body.
Terms on this page: metabolite Β· cut-off Β· detection window Β· presumptive result Β· confirmation test. More questions: LabX answers.
Test for Norbuprenorphine and 75 other compounds
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