Muscle relaxants, sedatives and analgesics

Does a drug test detect Butalbital?

Yes. Butalbital is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 100 ng/mL. The LabX 12-panel screen includes a Barbiturates line designed to pick up Butalbital. A screen is presumptive; adding laboratory confirmation identifies Butalbital specifically.

100 ng/mLLaboratory cut-off
100–10,000 ng/mLReportable range
1 day-3 weeksApprox. window (varies)
LC-MS/MSConfirmation method

What is Butalbital?

Butalbital is a barbiturate, an older class of sedative medicines. It is found in combination headache products.

Also known as or found in: Fioricet.

Medical use

Butalbital is prescribed in combination with acetaminophen or aspirin, and caffeine, for tension headaches.

How LabX tests for Butalbital

Butalbital is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports Butalbital as detected when its concentration is at or above the cut-off of 100 ng/mL, within a reportable range of 100–10,000 ng/mL. It is one of 9 compounds in the muscle relaxants, sedatives and analgesics family on the 76-drug confirmation panel.

Detection window

The laboratory's confirmation report lists an approximate detection window of 1 day-3 weeks for Butalbital. Treat that as a rough guide only: how long any compound stays measurable varies with the amount taken, how often it is used, body composition, metabolism, kidney and liver function, and hydration. A laboratory result cannot be used to work out when a substance was taken.

Screen versus confirmation

The LabX 12-panel screen includes a Barbiturates line designed to pick up Butalbital. A screen is presumptive; adding laboratory confirmation identifies Butalbital specifically.

Worth knowing

Butalbital is a common reason a barbiturate screen is positive. Confirmation identifies butalbital specifically, separating it from phenobarbital.

About this drug family

Muscle relaxants, barbiturates, nerve-pain medicines and acetaminophen, several of which are monitored in pain management and treatment programs.

Common questions

Does a drug test detect Butalbital?

Yes. Butalbital is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 100 ng/mL. The LabX 12-panel screen includes a Barbiturates line designed to pick up Butalbital. A screen is presumptive; adding laboratory confirmation identifies Butalbital specifically.

What is the laboratory cut-off for Butalbital?

LabX reports Butalbital as detected at or above 100 ng/mL, and the method's reportable range is 100–10,000 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.

How long can Butalbital be detected?

The laboratory lists an approximate window of 1 day-3 weeks, but it varies with dose, frequency of use, metabolism and hydration, and cannot be used to tell when something was taken.

Can a 12-panel drug screen detect Butalbital?

The LabX 12-panel screen includes a Barbiturates line designed to pick up Butalbital. A screen is presumptive; adding laboratory confirmation identifies Butalbital specifically.

Is Butalbital a prescription medicine?

Butalbital is prescribed in combination with acetaminophen or aspirin, and caffeine, for tension headaches.

Related compounds

Terms on this page: metabolite Β· cut-off Β· detection window Β· presumptive result Β· confirmation test. More questions: LabX answers.

Test for Butalbital and 75 other compounds

12-panel urine $89 or fingerstick blood $99, plus the 76-drug LC-MS/MS confirmation for +$89.

At-home drug tests and test kits are not currently available to addresses in New York, New Jersey, Rhode Island or California. Results are not a diagnosis β€” review them with a licensed physician.

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Talk to a licensed physician. LabX Diagnostics and Vantage provide laboratory testing only. The information on this page is educational and is not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about test results, symptoms or medicines, and before making any health decision. If you think you may have a medical emergency, call 911. Read our medical disclaimer.

Medical disclaimer. LabX Diagnostics and Vantage provide laboratory testing only. Test results and information on this site are for informational purposes and are not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about your results and before making any health decision. If you think you may have a medical emergency, call 911. Read the full disclaimer.

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